Formulation and Filling Line Isolators

Formulation and Filling Line

Esco partners with filling line companies to create a client-specific technology, which utilizes cGMP compliant isolators and high quality filling line accessories/technologies, to ensure product safety and sterility throughout the entire manufacturing cycle.​

Enclosure systems for this technology can range from open and closed Restricted Access Barrier Systems (o/cRABS) to leak tight isolation technologies compliant to international GMP standards.

Flexible Multi-format Ready-to-Use (RTU) Filling Line System

• Integrates the best industry technologies to simplify the manufacturing process. It utilizes flexible ready-to-use and single-use consumables, thus, removing container preparation process at the manufacturing site. It can also cater to multi-format containers and sizes on a single modular platform.​

• Combined manufacturing process that allows multiple container formats to be filled and finished on a single system.

• The use of RTU and single-use components lessens process delays and run time, as well as increases sterility of the process.​

• Subtypes:

  • Single Format

    1. Robotic

    2. Non-Robotic

  • Multi-Format

    1. Robotic

    2. Non-Robotic

Flexible Multi-format Ready-to-Use (RTU) Filling Line System Integrations:

• RTU consumables

• Single-Use Disposable Components:

  • Mixing bag/Holding bag​

  • Pre-filtration sampling bags​

  • Reservoir bags​

  • Aseptic connections/assemblies​

• Automated Tub Conveyor & Automated Nest Transporter​

• Robotic Arm (filling, stoppering, and capping)

• External Vial Washer​

• Additional Features

  • Stopper gap detection system

  • Quarantine location​

  • Inspection and labelling system

  • Viable monitoring (active and passive)

  • Modular in-situ​ configuration to have changeable parts to fill multiple container formats ​(e.g. RTU vials/ syringes/cartridges/IV bags)​