Isoclean® Healthcare Platform Isolator - With Filter Below Workzone

Optimized Solution for Sterile/Aseptic Applications

The Isoclean® Healthcare Platform Isolator (HPI-G3) facilitates the isolation of a product or process while providing the required sterile/aseptic environment. It is factory-configured to operate at positive or negative pressure in single or recirculating airflow. This equipment provides a comprehensive range of personnel and product protection in addition to the surrounding work areas and the environment.

The positive pressure HPI-G3 model is suitable for work involving non-hazardous materials, while the negative pressure isolator is suitable for work involving hazardous materials e.g. cytotoxic compounding applications.

The work zone and pass chamber interchange are either under positive or negative pressure to the room to maintain sterility or operator protection, respectively, in case of a breach in the barrier isolation system.

Key Benefits:

Unidirectional airflow of 0.40 ± 20% m/s provides superior protection for highly sensitive product
Class 2 containment enclosure on manual pressure leak test as per ISO 10648-2
Suitable for various applications such as pharmacy compounding, small-scale potent material handling, sterility testing, aseptic processing, research and development, and cell processing

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Features

Centrifugal, direct-drive blowers designed for maximum energy efficiency and minimal maintenance
Sentinel™ Gold Microprocessor Control System supervises all functions and monitors airflow and pressures in real-time
Type D2 Pass Chamber as per ISO 14644-7 with interlocked doors, adjustable purged duration, and time-delayed ingress/egress control allowing sufficient time for surface decontamination to minimize transfer of contamination
Removable sliding tray (option for perforated or non-perforated) prevents operator fatigue during transfer procedures
Electromagnetic Interlocking Doors with time delay effect ensures safety and containment between the Pass Chamber and the Process Chamber
Return Filter (option to upgrade to safe change BIBO) below work zone filters the contaminated air immediately to minimize possibility of airborne contamination
Foot switch provides hands-free access to opening of the Pass Chamber inner door minimizing operator fatigue during transfer procedures
HEPA H14 filters with a typical efficiency of >99.995% at 0.1-0.2 microns provide superior ISO Class 5 air cleanliness
LED Lamps deliver >650 as per NSF49 to the work surface for superior overall illumination
With ISO Class 5 environment, the Process Chamber facilitates aseptic processing in an EU GMP Grade A condition
Circular glove ports (200 mm diameter) with minimal crevices, no exposed bolts and nuts
Frameless tempered glass front visor panel with highly rounded edges to minimize crevices and maximize door vision panel
Single or upgradable to multiple, removable work trays for easy surface cleaning and decontamination
Optional adjustable hydraulic stand, with casters wheels, elevates to accommodate user preference for sitting or standing work surface height

Principle

Ambient air is pulled through the inlet pre-filter (>60% efficiency as per EN 779 for positive pressure model) located on top of the isolator. The pre-filter traps large size particles to extend the life of the supply HEPA (H14) filter.
Air from the top inlet and from work zone is pulled by the fan, which creates positive pressure on the plenum that creates downflow. Work zone pressure is always higher than the pass-through, to prevent contaminants from entering the work zone through the pass-through.
The downflow filter creates a full unidirectional airflow and particle-free ISO Class 5 environment inside the isolator to protect the work material inside the main chamber and pass-through. Air from the work zone and pass-through is quickly purged by the fans to keep the area clean.

Models

GENERAL SPECIFICATIONS Isoclean® Healthcare Platform Isolator (HPI-G3) (with filter below)		HPI-2G	HPI-3G	HPI-4G
Process Chamber Nominal Size (Width)		1215 mm (47.83")	1520 mm (59.84")	1825 mm (71.85")
External Dimensions (Wx D x H) - with 2 pass chamber	Without stand	2420 x 845 x 1560 mm (95.28" x 33.27" x 61.42")	2725 x 845 x 1560 mm (107.28" x 33.27" x 61.42")	3030 x 845 x 1560 mm (119.29" x 33.27" x 61.42")
	With SPC-A/SPL-A (713mm, 28")	2420 x 845 x 2273mm (95.28" x 33.27" x 89.49")	2725 x 845 x 2273 mm (107.28" x 33.27" x 89.49")	3030 x 845 x 2273 mm (119.29" x 33.27" x 89.49")
	With SPC-B/SPL-A (860mm, 34")	2420 x 845 x 2420mm (95.28" x 33.27" x 95.28")	2725 x 845 x 2420 mm (107.28" x 33.27" x 95.28")	3030 x 845 x 2420 mm (119.29" x 33.27" x 95.28")
	With STL/STC (660 to 885 mm)	2420 x 845 x 2220 to 2445 mm (95.28" x 33.27" x 87.40" to 96.26")	2725 x 845 x 2220 to 2445 mm (107.28" x 33.27" x 87.40" to 96.26")	3030 x 845 x 2220 to 2445 mm (119.29" x 33.27" x 87.40" to 96.26")
	With SHM (685 to 935 mm)	2420 x 845 x 2245 to 2495 mm (95.28" x 33.27" x 88.39" to 98.23")	2725 x 845 x 2245 to 2495 mm (107.28" x 33.27" x 88.39" to 98.23")	3030 x 845 x 2245 to 2495 mm (119.29" x 33.27" x 88.39" to 98.23")
Process Chamber Internal Dimension (W x D x H)		1215 x 624 x 610 mm (47.83" x 24.57" x 24.02")	1520 x 624 x 610 mm (59.84" x 24.57" x 24.02")	1825 x 624 x 610 mm (71.85" x 24.57" x 24.02")
Pass Chamber Internal Dimension (W x D x H)		577 x 410 x 320mm 22.72" x 16.14" x 12.60")
Pass Chamber Door Dimension (W x H)	Inner door	428 x 400 mm (16.85" x 15.75")
Pass Chamber Door Dimension (W x H)	Outer door	475 x 350 mm (18.70" x 13.78")
Airflow Regime		Factory Configured Recirculating or Single Pass
Pressurization		Factory Configured Positive or Negative Pressure
Glove Port Diameter		200 mm (Circular) Note: Oval glove port (200 x 300 mm) is optional as an upgrade
Glove Port Quantity		2	3	4
Chamber Environment		ISO Class 5 for all chambers (Grade A)
Process Chamber Downflow Velocity		0.4 +/- 20% m/s (1.31 fps)
Pre-filter		G4, panel, polyester fiber media
Downflow and Exhaust Filter Type		HEPA (H14) Filter with Integral Metal Guards and Filter Frame Gaskets; Fully Compliant With EN 1822 (H14) and IEST-RPCC001.3 Requirements
Filter Efficiency		>99.995% for particle 0.1-0.2 microns (MPPS, as per EN1822)
Lighting Level		>650 Lux
Sound Level		≤ 67 dBA
Isolator Construction	Main Body	1.2 mm (0.05”) 18 gauge electro-galvanized steel with white oven-baked epoxy-polyester antimicrobial powder-coated finish
Isolator Construction	Work Tray	1.5 mm (0.06”) 16 gauge stainless steel, type 316L, with 4B finish
Electrical	220-240V, AC, 50 Hz, 1Ø	HPI-2G8-_ _ _ - _	HPI-3G8_-_ _ _ - _	HPI-4G8_-_ _ _ - _
	Cabinet Full Load Amps (FLA)	10 A	12.1 A	12.1 A
	Optional Outlets FLA	10 A (5A per outlet)	10 A (5A per outlet)	10 A (5A per outlet)
	Cabinet Nominal Power	493 W	TBD	TBD
	Cabinet BTU	1682 BTU/hr	TBD	TBD
	110-120V, AC, 50 Hz, 1Ø	HPI-2G9-_ _ _ - _	HPI-3G9_-_ _ _ - _	HPI-4G9_-_ _ _ - _
	Cabinet Full Load Amps (FLA)	20 A	20 A	20 A
	Optional Outlets FLA	10 A (5A per outlet)	10 A (5A per outlet)	10 A (5A per outlet)
	Cabinet Nominal Power	TBD	TBD	TBD
	Cabinet BTU	TBD	TBD	TBD
Options/ Accessories	Adjustable Hydraulic Stand	✓	✓	✓
	Carbon Filter	✓	✓	✓
	CCTV	✓	✓	✓
	Drain	✓	✓	✓
	Electrical Outlet	✓	✓	✓
	Glove Leak Tester	✓	✓	✓
	IV Bar with S hooks	✓	✓	✓
	UV Lamp	✓	✓	✓
	Rear View Screen Adaptation	✓	✓	✓
	Single-piece Trays	✓	✓	✓
	Multiple-piece Trays	✓	✓	✓
	Anti-blow Back Valve (ABBV)	✓	✓	✓
	Minibioatom decontamination	x	x	x
	Automated Pressure Hold Test	x	x	x
	Sharps Disposal	✓	✓	✓
Shipping Weight**		835 kg (1840.47 lbs)	967 kg (2133.33 lbs)	1100 kg (2425.08 lbs)
Shipping Dimensions, Maximum (W x D x H)		2600 x 1050 x 2512 mm (102.36" x 41.34" x 98.90")	TBD	3200 x 1050 x 2512 mm (125.98" x 41.34" x 98.90")

Note:

** Weight is a rough estimation, including support stand SHM. Contact Esco for more details
* Add 260 mm height, with Top Exhaust Collar
* No height difference with Carbon Filter
* Adjustable hydraulic stand is not recommended for hard-ducted unit

Building Exhaust Requirement		HPI-2G	HPI-3G	HPI-4G
Recirculating	1 pass chamber	531 cmh @ 200 Pa	647 cmh @ 250 Pa	765 cmh @ 300 Pa
Recirculating	2 pass chamber	595 cmh @ 250 Pa	711 cmh @ 300 Pa	828 cmh @ 350 Pa
Total Exhaust (Single Pass)	1 pass chamber	1062 cmh @ 400 Pa	1295 cmh @ 500 Pa	1530 cmh @ 600 Pa
Total Exhaust (Single Pass)	2 pass chamber	1189 cmh @ 500 Pa	1422 cmh @600 Pa	1657 cmh @ 700 Pa