Dynamic Passboxes / Dynamic Floor Laminar Hatches (DPB/DFLH)
Esco Dynamic Passboxes (DPB) and Esco Dynamic Floor Laminar Hatches (DFLH) are aseptic architectural systems used to prevent contaminants from leaking into aseptic suites. They are utilized for aseptic transfer of materials into and out of the critical process environments.
Cleanroom and Controlled Environments
Easy to clean design
Material of construction of DPB/DFLH is full stainless steel with interior rounded/ coved corners at its base which is easy to clean.
HEPA H14 filtration with ISO Class 5/ Grade A environment within the chamber
DPB/DFLH has HEPA (H14) knife edge gel-sealed main filter and G4 pre-filters to increase the main filter lifespan.
Simple switches or Sentinel™ Gold microprocessor control
Selection from simple rocker switches or Sentinel™ controller with audio/visual alarms for downflow velocity and filter loading
Indicator lights provision
Red/green indicators lights to signal door status
Emergency stop button located on both sides of the unit
Internal chamber visibility
Tempered glass viewing window
DPB/DFLH has electromagnetic interlocking doors to prevent both doors from being opened at the same time
Full stainless steel construction
DPB/DFLH exterior and interior are full SS 304 material of construction with stainless steel hinges
Enhanced perforated grille system
Coved corners at the base with enhanced perforated grille system for full downflow in critical corners
HEPA filter integrity testing capability
PAO injection port provision for HEPA filter integrity test
Flanges ensure there's no space in between the wall and unit upon installation
Differential pressure across filter monitoring
Selection between magnehelic gauge or digital display of differential pressure value across filters (via SentinelTM Gold controller with filter load alarm)
Dynamic airflow provides an air barrier to prevent contaminants from entering into critical controlled environments during material transfers
Vertical purging to trace any contaminants that have potentially entered post material transfer.
Unit operates with a recirculating airflow and on-board fans hence, external ducting is not required.
A-EG Steel Exterior/Interior with SS304 base.
1 - With
1 - With
1 - With
S1-Full SS304 with
interior rounded corners
2 - L shape
2 - Without
2 - Without
2 - Without
S2-Full SS316L with
interior rounded corners
3 - 3 way
Support stand or Base box
Onboard LED light and/or UV light
Door release buttons
Interlock release rocker switches
Buzzer system (to alert personnel on the opposite side during material transfer)
Fan fault alarms with customized blowers
Roller Conveyors (only for DFLH)
Auto sliding PVC doors (only for DFLH)
Rails to hang gowns (only for DFLH)
How do dynamic pass boxes (DPB) differ from dynamic floor laminar hatches (DFLH)?
DPB are wall mounted units, and can be provided with support stands. While, DFLH on the other hand are floor mounted.
What is the difference between static and dynamic pass boxes in terms of application?
Dynamic pass boxes or dynamic floor laminar hatches (DPB/DFLH) have built in blower and filter, and can provide ISO Class 5/ Grade A clean air within the unit.
Unlike static pass boxes with no airflow inside, DPB/DFLH are more suitable for material transfer in between controlled and uncontrolled rooms and/or for controlled rooms with different cleanliness grades.
What airflow pattern does DPB/DFLH operate in?
Standard design of DPB/DFLH runs at a recirculating mode. During operation, room air is drawn to the DPB/DFLH unit and passed through a G3 prefilter, trapping larger particles and increasing the life of the main filter.
Downflow air is then forced evenly through the H14 knife edge gel sealed filter resulting in a unidirectional stream of clean air projected vertically over the internal chamber.
The purified air then recirculates via a G3 prefilter before passing through the H14 filter for downflow supply of air.
Depending on the requirement, it is also possible to design DPB/DFLH to be single pass with air intake and exhaust. This may incur customization costs.
What is the typical efficiency of the filters used for DPB/DFLH?
G3 prefilter with 85% arrestance, and HEPA H14 filter with typical efficiency of >99.995% for particle sizes of 0.3 microns.
How does DPB/DFLH differ from other pass through cabinets offered by Esco?
Esco Pharma has 4 types of pass through cabinets with varying features and capabilities, these include:
Static pass boxes
Esco static pass boxes (EPB-A, EPB-B, SPB) and cleanroom transfer hatches (EPB-S) are situated in between cleanroom or controlled environmentsf to facilitate in the aseptic transfer of material/s in order to mitigate cross-contamination risks.
Dynamic pass boxes and Dynamic Floor Laminar Hatches (DPB/DFLH)
Unlike static ones, DPB/DFLHare aseptic architectural systems which can provide ISO Class 5 as per ISO 14644-1 (Grade A as per EU GMP) environment within the chamber. DPB/DFLH are stand alone units which havebuilt-in pre-filters, HEPA filter and blower integrated within.
Esco air shower pass boxes (EAS-PB)
EAS-PB works similarly to DPB/DFLH whereair is being provided to the internal chamber of the unit except that for EAS-PB, air tis only supplied for a limited duration.
EAS-PB utilizes high velocity air jets which run at 18-30 m/s to provide a “scrubbing” effect to particulate matter or surface contaminants which may potentially be present on the material/s being transferred between rooms.
BioPass™ Pass Through
The design of BioPass™ Pass Through is similar to a dynamic floor laminar hatch (DFLH) wherein both are floor standing units with built in blowers, and is maintained with an ISO Class 5 as per ISO 14644-1 (Grade A as per EU GMP) clean air supply within.
In contrast to the other pass throughs, Biopass™ is integrated with a hydrogen peroxide (H202) based biodecontamination system within and it is designed for r passing through of relativelylarger equipment/ materials into the chamber.
What is the standard operating sequence of DPB/DFLH?
- When one door is opened, the opposite door will be locked (indicator light is red)
- Once the door is closed, both doors will be locked for a specified amount of time to purge potential contaminants that may have leaked into the chamber. (indicator light is red)
- Once the purging time & purging process is done, both doors will remain closed but will be unlocked. Hence, either door is ready to be pulled open. (indicator light is green)
- In case the unit is customized to have an add-on optional door release button, the doors will always be locked. The only time a door can be pulled open is by pressing the door release button first to unlock a door. Once unlocked, only then can the door be pulled open.