Operational Excellence Aseptic Platform Isolator

• Integrated NHP bio-decontamination. The Nebulized Hydrogen Peroxide system is designed to achieve a 6-log microbial reduction. Fine aerosol distribution supports coverage throughout the main and transfer chambers while enabling faster bio-decontamination cycles.
• Heavy gauge chamber construction. The 3.0 mm SS316L work chamber has fully welded joints and coved internal corners for durability and ease of cleaning.
• Rear wall racking and hanging bar. Integrated mounting points and a hanging bar support convenient process access and effective bio-decontamination exposure.
• Space saving sliding internal door. The sliding door between the main and transfer chambers minimizes intrusion into the working area and maximizes usable chamber space.
• Integrated controls and records. A 15-inch Allen-Bradley HMI and PLC provide centralized operation and monitoring, data logging, and PDF cycle reports.
• Catalytic converter coverage. Converters treat air from every chamber exhaust and the main-chamber recirculation loop to reduce hydrogen peroxide exposure during aeration and normal operation.
• Four glove main chamber. Four glove ports provide access across the 1900 mm-wide isolator chamber. Non-gloved transfer chambers support material transfer between the working area and surrounding room.

Other Features

Details marked † are retained from the original draft and require engineering confirmation before publication.

• Filtration. H14 HEPA supply and exhaust filtration supports a controlled aseptic environment.
• Pressure integrity. Automated chamber integrity testing is performed before each decontamination cycle. The system is designed to meet <5% chamber volume per hour (prior to each decontamination)
• Door seals. Inflatable seals on all doors support the chamber barrier.
• Environmental monitoring. Real-time temperature and relative humidity monitoring is standard in all chambers. Viable air samplers and non-viable particle counters are available as options.
• Particle monitoring integration. Mechanical and control provisions support particle-monitoring equipment integration.
• Facility integration. A standard relay contact supports connection to facility systems.

Confirm the availability and scope of each marked feature before removing the review markers. Brochure-confirmed specifications and accessories are listed in their respective sections.

OxAP is available with a four-glove main chamber and either one transfer chamber on the left or right, or two transfer chambers on the left and right. All configurations operate under positive pressure.

Model code guide

OX-AP-4G-P-B

The Operational Excellence model family also includes ST for Sterility Testing (OxST).

Overall unit dimensions

Dimensions from the original webpage draft are retained below for review and require confirmation against the approved engineering drawing.†

• Four gloves with one transfer chamber: 3065 × 1080 × 2430 mm (W × D × H).†
• Four gloves with two transfer chambers: 3747 × 1080 × 2430 mm (W × D × H).†

OxST sterility testing variant

The Operational Excellence family includes OxST for sterility testing. The original draft describes this variant as incorporating an integrated sterility test pump, a floor-level drain, and a cable pass-through for foot-pedal operation.† These provisions support sterility testing workflows; the exact standard configuration and any dimensional differences require confirmation.

Chamber specifications

Dimensions above refer to the chamber dimensions listed in the brochure, rather than the overall installed unit footprint.

Constructions and performance

Bio-decontamination controls and utilities

The following options are available for the OxAP platform.

Controlled airflow

The main chamber provides a Grade A / ISO Class 5 environment with unidirectional, partially recirculating airflow. Transfer chambers use turbulent, single-pass airflow. Positive pressure is maintained at +40 ± 5 Pa in the main chamber and +20 ± 5 Pa in the transfer chambers to help prevent ingress of contaminants from the surrounding room.

Air enters through the upper front inlets, passes through inlet filters and supply fans, and flows downward through supply filters into the chambers. It is drawn beneath the chamber grilles and through exhaust filtration and catalytic treatment. A portion of the main-chamber air recirculates, while transfer-chamber air is fully exhausted. Exhaust air is discharged through the side of the unit.

Controlled material transfer

Materials enter and leave through dedicated transfer chambers, protecting the main working area from direct exposure to the surrounding room. Materials are loaded onto an integrated sliding tray. After the outer door is closed and sealed, the transfer chamber runs its own bio-decontamination cycle before the inner-door interlock releases. The tray then extends into the main chamber, bringing materials within operator reach and reducing reach distance and glove fatigue.

The reverse process applies to material removal. Interlocked door sequencing prevents the inner and outer doors from opening simultaneously, avoiding a direct air path between the room and main chamber.

Independent chamber bio-decontamination

The main chamber and each transfer chamber have independent bio-decontamination capabilities. The main chamber can be decontaminated before or after a batch without cycling the transfer chambers. Transfer chambers can be decontaminated between material transfers while maintaining the main-chamber environment. Cycles are independently validated, documented, and traceable.

An automated pressure-hold test is performed before each decontamination cycle, with a leakage criterion of less than 5% of chamber volume per hour.