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Levigation is the process of decreasing the particle size of powders via triturating them with a mortar and pestle along with a small amount of liquid wherein the substance is insoluble to. This specific liquid is called a levigating agent and is viscous in nature with a low surface tension to easily wet the solid particles. Such agents also act as a lubricant as they also allow a smoother incorporation of solids in the preparation.

Methods of Levigation:

  • Small-scale via mortar and pestle
  • Large-scale via runner mills


  1. Rana, H., Husnain, M., & Ahmad, M. (n.d.). Levigation [PowerPoint Slides]. SlideShare. Retrieved from:
  2. Mangine, D. (2017). Compounding Techniques for the Simulation Lab. Simtalk Blog. Retrieved from:

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