Containment Barrier Isolators - H: Hybrid (CBI-H)

Your Practical Solution to cGMP Compliance

Containment Barrier Isolator - Convertible Class III/Class I Biosafety Cabinet (CBI-H) builds on Esco Healthcare’s success of CBI-III. It allows operators to work via a removable glove visor to convert the cabinet and function as a Class III or a Class I Biosafety Cabinet as per EN 12469 standards. In BSC Class III mode, the operator works through a glove port attached to a removable panel. It can be converted to a BSC Class I by removing the closure panel and attaching a blanking plate over the inlet HEPA filter.

To ensure maximum performance, commissioning and preventive maintenance of the cabinet must be done in both modes.

Applications:

Laboratory containment for handling biological agents of up to level 4
Research and development

Request for Quotation

Features

Fully welded stainless steel 316L internal chambers with stainless steel 304 external housing
Designed to operate as a Class III BSC to Class IIII BSC or as Class I BSC
In Class III BSC mode, access to the work zone is through the gloves/gauntlets set into a removable panel
Converted to Class I BSC by removing the panel and closing the air inlets on both sides
Easy to clean inside and out; easy to maintain

Principle

containment barrier isolator h (cbi-h) airflow scheme

Class I BSC Mode

Cabinet can be converted to a Class I BSC Mode by simply removing the front glove port attachment panel. Ambient air is pulled inside the work zone and is exhausted out of the cabinet by passing through a HEPA (H14) filter prior to exhaust.

Class III BSC Mode

Ambient air is pulled through the inlet pre-filter and HEPA (H14) filter located at the both sides of the cabinet. The HEPA (H14) filter provides particle-free ISO Class 5 air cleanliness as per ISO 14644-1. Air from both the pass-through chamber and main chamber is pulled to the top portion through a HEPA (H14) filter and is 100% exhausted out of the cabinet through a dedicated ducting system.

Models

GENERAL SPECIFICATIONS Containment Barrier Isolator - Hybrid (Convertible Class III/Class I Biosafety Cabinet)		CBI-H-2G	CBI-H-3G	CBI-H-4G
Main Chamber Nominal Size (Width)		1.2 meter (4’)	1.6 meter (5.2’)	2.0 m (6.6’)
Working Chamber Dimensions - Min (W x D x H)		1.20 m x 0.55 m x 0.77 m (3.9’ x 1.8’ x 2.5’)	1.60 m x 0.55 m x 0.77 m (5.2’ x 1.8’ x 2.5’)	2.0 m x 0.55 m x 0.77 m (6.6’ x 1.8’ x 2.5’)
Working Chamber Dimensions - Max (W x D x H)		1.20 m x 0.63 m x 0.84 m (3.9’ x 2.1’ x 2.8’)	1.60 m x 0.63 m x 0.84 m (5.2’ x 2.1’ x 2.8’)	2.0 m x 0.63 m x 0.84 m (6.6’ x 2.1’ x 2.8’)
External Dimension (with one Pass Chamber) (W x D x H)	With Adjustable Base Stand (Min)	1.82 m x 0.92 m x 2.55 m (6.0’ x 3.0’ x 8.4’)	2.22 m x 0.92 m x 2.55 m (7.3’ x 3.9’ x 8.4’)	2.62 m x 0.92 m x 2.55 m (8.6’ x 3.0’ x 8.4’)
	With Adjustable Base Stand (Max)	1.82 m x 0.92 m x 2.85 m (6.0’ x 3.0’ x 9.4’)	2.22 m x 0.92 m x 2.85 m (7.3’ x 3.9’ x 9.4’)	2.62 m x 0.92 m x 2.85 m (8.6’ x 3.0’ x 9.4’)
External Dimension of Pass-through Chamber (W x D x H)		0.62 x 0.66 x 0.58 m
Glove Port Height (Min)		1200 mm	1200 mm	1200 mm
Glove Port Height (Max)		1500 mm	1500 mm	1500 mm
Chamber Environment		ISO Class 5 all chambers (Grade A)
Airflow	Class III	Turbulent
	Class I	Unidirectional (Positive)
Pre-filter	Process Chamber	G4, polyester media
	Pass-through Chamber	G4, polyester media
Filter Type - Chamber Inlet		HEPA (H14) Filter with Integral Mesh Guard and Gasket Seal
Filter Efficiency - Chamber Inlet		99.995% MPPS
Filter Type - Chamber Exhaust - 1st Stage		HEPA (H14) Filter with Integral Mesh Guard and Gasket Seal
Filter Type - Chamber Exhaust - 2nd Stage		HEPA (H14) Filter with Integral Mesh Guard and Gasket Seal or Carbon Filter
Filter Efficiency - Chamber Exhaust - 1st Stage		99.995% MPPS
Filter Efficiency - Chamber Exhaust - 2nd Stage		99.995% MPPS
Lighting Level		≥ 500 Lux (6000 K)
Sound Level		≤ 80 dBA
Isolator Construction	Chamber	SS 316L
	Service Housing	SS 304
	Support Frame	SS 304
Isolator Finish	Chamber Internal	≤ 0.4 Ra
	Chamber External	≤ 0.6 Ra
	Serivce Housing External	≤ 0.6 Ra
	Support Frame	≤ 1.0 Ra
Electrical Requirements	220-240 VAC, 50/60 Hz, 1Ø	CBI-H-2G8	CBI-H-3G8	CBI-H-4G8
(by Client)	110-120 VAC, 50/60 Hz, 1Ø	CBI-H-2G9	CBI-H-3G9	CBI-H-4G9
Compressed Air Requirement (by Client) If no on-board compressor	2 Bar-g Pressure at 5 L/sec	✔	✔	✔
Exhaust Duct Requirements (by Client) unless Integral Catalytic Convertor is Included		10” Duct from Isolator to Outside
Net Weight		TBD	TBD	TBD
Shipping Weight		TBD	TBD	TBD
Shipping Dimension (W x D x H)		TBD	TBD	TBD
Shipping Volume (Maximum)		TBD	TBD	TBD

Accessories

LIST OF OPTIONS for CBI Models		CBI-U	CBI - T	CBI-III	CBI-H
4" Split Butterfly Valve (for powder discharge of powder below isolator chamber)		✔	✔
Adjustable Hydraulic Stand (based on operator ID input)		✔		✔	✔
Exhaust Box (with automated dampers with inflatable seals or manual with valve)		✔		✔	✔
Anti-blow back damper box		✔	✔		✔
Automated Pressure Hold Test	with Client Supplied Compressed Air	✔	✔	✔	✔
Automated Pressure Hold Test	with On-board Air Compressor	✔	✔	✔	✔
Bag Welder with Table Bag-out Port		✔	✔	✔
Bio Dunk Tank Bag Out Port				✔	✔
Mobile Biodecontamination BioVap TM		✔		✔	✔
Carbon Filter		✔
Convertible to Class 1 cabinet					✔
Integration of small scale aseptic or potent tablet/capsule etc…		✔	✔	✔	✔
Double-sided access			✔	✔	✔
Manual Drain Ball Valve (for client controlled CIP/WP) must order with inner pass-through inflatable sealed doors.		✔	✔
Electrical Outlet (IP66)	IP 66	✔	✔	✔	✔
Electrical Outlet (IP66)	ATEX Zone 1/21 (only for internal environment)	✔	✔		✔
ATEX rating up to zone 1/21 internally only (ATEX fan, “IS” signals for internal door sensor/push button)		✔	✔
Glove Leak Tester		✔	✔	✔	✔
Formalin Vaporizer (auto neutralization and purge cycle)		✔		✔	✔
H₂O₂ Monitoring (sensor is not integrated with HMI)		✔		✔	✔
Liquid Water Entry / Exit Ports				✔	✔
N2 Purge for Process Chamber			✔
Ø250 mm Product Waste Bag Out Ports /				✔
Battery option to maintain EM interlock during power outage or E Stop		✔	✔	✔	✔
Particle Counter	Portable Paricle Counter (Non-viable)	✔		✔	✔
Particle Counter	Microbial Air Samples (Viable Particle Counter)	✔		✔	✔
Product Waste Entry / Exit Ports		✔			✔
RTPØ 105, 190, 270 - Alpha		✔	✔	✔	✔
RTPØ 105, 190, 270 - Beta Canister		✔		✔
RTPØ 105, 190, 270 - Beta Liner		✔		✔
RTPØ 350, 460 - Alpha, Beta Liner, Beta Canister			✔	✔	✔
Service Fixtures (Vacuum, Nitrogen, Compressed Air, Nozzle for BioVap)		✔	✔	✔	✔
Spray Ball (CIP) with Manual Ball Valve			✔
Spray Gun (WIP) with Manual Ball Valve		✔	✔
Sterile Continuous Liner		✔		✔	✔
Sterility Test Pump		✔
Temperature and Relative Humidity Monitoring (only for process chamber)		✔	✔	✔	✔
Rear view monitor		✔	✔	✔	✔
UV Lamp				✔	✔
Weighing Scale Granite Slab		✔	✔		✔
Sharps (inside)		✔