Adapted Dosage Form

• Taste of Drugs

Preferences of children in term of taste are quite fundamentally different from those of adults. Classically sweet candy flavors are preferred by children. As the original taste of active pharmaceutical ingredients and fillers can be unacceptable, the Europeans Medicine Agency (EMA) has published a list of recommended flavors depending on the original taste of Active Pharmaceutical Ingredient (API) (acid, alkaline, bitter, salty, and sweet). There is also a proposal for flavors usually associated with treatment of different disease (vitamins and lemon/orange, stomach pain and mint flavors, etc.)

Cultural factors also have to be taken into account, even if a company cannot produce the same medicinal products with different tastes according to country preferences. The simplest example from the sweet industry is the liquorice taste which is a ‘must’ in Nordic countries where, for example, some salty liquorice ‘sweets’ exist under various brand names and are called “salmiak” or “salmiakki”.

• Drug Administration Techniques for Children

Generally even if there is no ideal formulation, for children the following considerations must be taken into account: a minimal dosage frequency must be chosen, and normally one dosage form must fit all or a full range of products; developers must present a drug that has a minimal impact on life style with minimum toxic excipients. The drug must also be convenient, easy to use, with reliable administration. It must be easily produced, with a good stability and it must have low cost and a good commercial viability. Oral administration can be achieved via several types of dosage forms; generally for children less than 6 years, oral solutions or suspension are commonly used. We can also find oral flexible dosage form presented as granules, pellets or powders that allow an easy reconstitution in solution/suspension and avoid any problems of swallowing for the younger children.

Different objectives can be defined. The first one is to help parents to administer medicines, another is to help parents make treatment acceptable to children, and lastly to help children take their own medicine and increase their autonomy. Depending on the age, these factors are different. For example for babies and newborns a passive administration is the norm. They do not know what a drug is; drugs that can be administered are presented as powders, solutions or suspensions and some are prepared and mixed by parents with the baby's milk, sometimes with added sugar. When the children become older, the adults can try to explain and convince them to take a treatment/themselves.

Some alternatives have been developed such as active management: nipples, pacifiers or lollipops with double use (child can play them while absorbing a dose of medication). The suppliers, as well as parents, must be warned because systems must be totally different from the original and exhibit an obvious difference so as to avoid any confusion or over consumption. For example, strips and ibuprofen chewing-gum actually exist in USA for pain killer administration.

• Metering Systems for Oral Administration in Children

Following age and weight specificities, the product must be dosed correctly. From the beginning of the century up to the 1950's, specific glass bottles showing spoons measurements were used allowing an accurate dosage of product. This system was available and useful for preparations made directly by the pharmacist.

Following industrialization, this was abandoned and replaced by household spoons up to the 1980's but for pediatric solutions or suspensions, the use of spoons or half spoons led to specious accuracy as it appears that there are considerable differences within households. Even if experts can say or claim that there is a low risk of harm due to these differences, the accuracy of dosage with these spoons is not good.

The idea of standardization was revisited with adaptations of specific spoons or mini glasses included in the medication boxes with different systems. The first type of system still comprised of spoons with fixed volumes corresponding to a full or half a spoon.

The second generation of devices was developed based on concepts of having a simpler accurate and reliable dosing. It could be considered as a rupture in the prescription strategy. It is based on a simplification of their use by the parents involving a modification of the protocol prescribed by the medical doctors based on kg of body weight. For example the M-T-Spoon® that offers different forms of 'spoon like' measurements or a reliable dose corresponding to the weight of the children in kg. Some spoons are clipped directly attached to the bottle and allow the correct dosing system and the correct drug.

The next step was the modification from a passive tool to a more active one, involving not only the action of filling a reservoir but pulling the plunger of a syringe, the bottle being in this case safely on the table avoiding any risk of being knocked over. The first example of this system was the Adapta-dose® syringe that measures a prescription of emulsion, solution or suspension according to the weight of children. All these systems can help to deliver the right dose but clear instructions.

All these packaging and metering systems are easy to use and present good accuracy. However, some problems can appear with dosing syringes as reported by some health authorities because pressure of delivery can sometimes lead to problems in swallowing. This suggests the need for new systems with mandatory low pressure administration.

Other systems are also appearing for oral dosage and administration. For example, in 2001, a well-known French designer, Matthieu Lehanneur, has proposed 'therapeutic objects' that use different systems to treat disease (they have now found their place in one of the most famous museums in the world, the Museum Of Modern Art—MOMA—in New York). One of these objects is 'the sleep wand' integrated with a straw to relieve problems of insomnia. In this case the technique involves infusing a 'wand in a glass of water and waiting for it to soften before drinking the mixture. Industrially the idea of the straw has been employed, as a conservation and dispensing device. One example of such a product is associated with probiotics contained in the straw which are added to an effervescent tablet of vitamins just before administration.

New straw devices are appearing as safe dosing systems for different API in granulates. The straw allows storage of products with also a reliable measure of the dose and generally children love to drink liquid with a straw. The use of the straw helps in drinking thicker liquids and is fun for children [19]. With this new system, the medicine can then be either administered by smoothly shooting the straw into the patient’s mouth (passive administration) or by adding it to a drink and sipping it through the syringe (active administration). Another example is the old glass vial, redesigned and associated with a straw to give a new system that can be easily employed with all API requiring a glass for stability. In this case, the vial is employed in a glass single dose system and it is opened with a peel back lid and drunk with a straw; different vial sizes are available.

• Drugs for Children and Designer Work

As an example, Anne-Charlotte Legrand, a young designer has chosen to present a new approach for targeting children between 3 and 6 years old. She focused on three minor pathologies very frequent in childhood: injuries, fever and pain, and pulmonary problems. The designer has presented a range of different products named Tamalou® that need a preparation time considered as a medical digression during which the child will participate in the medication. This moment can be between the eating times and play time and it can be considered as a learning time (for better adherence) which allows for dialogue to explain the disease. Further, we can limit the passivity of children when confronted with their illness and explain to them the importance of taking care of themselves. Each product operates following the same pattern: mother prepares and explains things to the child (often with a nice story presented in a booklet), and once the system is prepared, she entrusts the device to the child so that he or she can participate actively in the care. For example a paracetamol strip, a system which allows dispensing the strip in centimeters cut according to body weight. The choice of length is directly related to the concept of graduation syringe dosage used with liquid form. In that case designer's work is adapted to the solid dosage form.

Two other Tamalou's devices are proposed with a similar idea for preparation by the parent before giving it to the child. One is a felt, is impregnated with antiseptic swabs where the parent prepares the buffer and applies it as a magic wand. The last one is a booklet with pictures impregnated with a balm with essential oils to sooth the bronchial passage that relieves symptoms (e.g., for a cold...) and tells a story.

These systems have been developed in order to allow the child to be involved as a player in their treatment because work is also in direct relation to the child partner hypothesis where the child can be involved as a player in the observance of his treatment because a drug well taken will be more efficient.