Containment Barrier Isolator - Unidirectional

Your Practical Solution to cGMP Compliance

Containment Barrier Isolator - Unidirectional (CBI-U) utilizes unidirectional/laminar airflow and facilitates the isolation of a product or process while providing the required conditions (ISO Class 5/ Grade A Environment) for a sterile/aseptic environment. This equipment provides a comprehensive range of personnel and product protection in addition to protection for the surrounding work areas and the environment.

It is factory-configured to operate at positive or negative pressure in single pass or recirculating airflow. The type of application dictates the operating parameters (pressure/airflow) of the CBI-U.


  • Pharmacy Compounding (Chemotherapy/TPN)
  • Small-scale Potent Material Handling
  • Aseptic Processing
  • Sterility Testing
  • Research and Development
  • Cell Processing



  • Controls exposure/cross-contamination risk to hazardous/aseptic materials for a wide variety of equipment and processes

  • Controls false-positive risk for sterility testing

  • Provides Operator Exposure Levels (OEL’s) ≤1.0 μg/m3 during controlled operations

  • Levels of ≤0.1 μg/m3 can be achieved via closed-transfer processes or based on client SOPs

  • Enhances cGMP practices

  • Quiet, energy-efficient ECM fans auto adjust to compensate for filter blockage

  • Standard dimensions available are easily customized to suit process requirements

  • Safe glove change and low contamination filter change

  • FDA-approved static seals

  • Class 2 containment enclosure on manual pressure leak test and Class 3 containment enclosure on automated pressure test as per ISO 10648-2

  • System comes with a Semi-automated or Automated Pressure Hold Testing

  • Pass Chamber comes in 2 sizes:

    • Small, non-gloved

    • Large, non-gloved/gloved

Esco Group of Companies