Why CBI?

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Esco Containment Barrier Isolator (CBI) facilitates the isolation of a product or process while providing the required conditions for a sterile/aseptic environment. It is configured to operate at positive or negative pressure. This equipment provides a comprehensive range of personnel and product protection in addition to protection for the surrounding work areas and the environment.

CBI's design has complete compliance to PIC/s and EU cGMP standards with its 19 mm radius coved internal corners in a single piece chamber (no perforations or grilles for contaminants to be trapped on all 4 corners). Its Rear Return Filter ensures that ducts are not contaminated. The system comes in either recirculatory or single pass airflow.

  • Pharmacy Compounding (Chemotherapy/TPN)
  • As a Class III Cabinet for Biosafety Levels (BSL) 3 and 4
  • Small Batch Sterility Testing
  • Small-scale Potent Material Handling
  • Cell Processing
  • Aseptic Processing
  • Research and Development


  • Controls exposure/cross-contamination risk to hazardous/aseptic materials for a wide variety of equipment and processes

  • Controls false-positive risk for sterility testing

  • Provides Operator Exposure Levels (OEL’s) ≤1.0 μg/m3 during controlled operations

  • Levels of ≤0.1 μg/m3 can be achieved via closed-transfer processes or based on client SOPs

  • Enhances cGMP practices

  • Quiet, energy-efficient ECM fans auto adjust to compensate for filter blockage

  • Standard dimensions available are easily customized to suit process requirements

  • Safe glove change and low contamination filter change

  • FDA-approved static seals

  • Pressure tested class 1 ISO 10648-2 standards

  • System comes with a Semi-automated or Automated Pressure Hold Testing

  • Pass Chamber comes in 2 sizes:

    • Small, non-gloved

    • Large, non-gloved/gloved

  • Pass-Through Chamber – comes in 2 sizes: Small with no glove ports and Large with optional glove ports.

    CBI with 2 Large Pass-Through Chamber, Gloved

    CBI with 2 Large Pass-Through Chamber, Non-Gloved

  • Stand-alone Biodecontamination System

  • Non-Viable and Viable Air Sampler

  • Rapid Transfer Port

  • Foot Switch

  • Integrated Sterility Pump

  • Weighing Scales

  • Spray Gun

  • Temperature & Humidity Monitor

  • Hydrogen Peroxide Monitor

  • Product Waste Entry/Exit Ports

  • Liquid Waste Entry/Exit Ports<

  • Butterfly Valve

  • Drain

  • Liner System

  • CCTV Integration and Provision

  • Rear View Access Provision

  • Sharps disposal

  • Automated Pressure Hold Test with Client-Supplied Compressed Air or On-Board Air Compressor

    Compressed Air Supply Port (by client)

  • Automated Damper Closure for Pressure Testing