Raising Your Standards with Esco Downflow Booth
Airflow Containment on Its Best

Nov 29, 2017

The fundamental principle of Downflow Booth is to provide operator protection during the handling of nuisance, toxic, or sensitizing products either in a powder or liquid form. Air is delivered to the Operator’s Breathing Zone (OBZ) through the overhead HEPA filters, thus providing a clean and safe environment. Potential dust clouds are suppressed and removed into the exhaust filtration system.

The operator carries out tasks in the high-velocity zone at the rear of the Booth so that dangerous dust will not rise into the breathing zone.

Downflow Booths are versatile equipment that can:

Esco Downflow Booths can be widely used for many different applications to various industries such as providing contamination control for operators. Typical applications include dispensing, sub-division, milling and grinding, process pack off and charging. These are used in applications that require high-degree of flexibility for containment assurance. The standard open layout allows easy access for both personnel and materials entry. Although the standard Booth range offers a practical solution to most operations, customising the size and layout to suit other processes and product requirements can also be done. End user involvement is actively sought at all stages, from the design to the built of the equipment, creating a flexible and controlled facility to suit the changing work practices.

Operator protection can also be acquired by customizing the layout of the booth and integrating high containment screens and personnel and material airlocks.

High containment screens provide an actual physical barrier between the operator and the product. The operator works through large ergonomically positioned oval glove ports with Hypalon glass. High containment screen allows multi direction movement for the operators’ freedom to move left, right, front, back, and even rotate whilst being protected. From OEL of ≤100 µg/m³, the integration of this screen gives as much as ≤10 µg/m³ over an 8-hour TWA.

An example of a lay-out of a Downflow Booth (DFB) integrated with High Containment Screen.

Aside from High Containment Screens, customized operator workstation can also be done. All powder handling operations are kept behind the door where the exhaust flow is the greatest. Operator is totally segregated from the product, thus, this arrangement is particularly useful for levels between 10 to 50 µg/m³.

The integration of split level workbench for powder subdivisions.


Split level workbench is designed to suit applications which involve sub dividing products from larger drum to smaller container.

Airlock Booths are used to ensure that no contaminated air enters the booth from the warehouse area. Incoming air is controlled by positively charging the airlocks with HEPA-filtered air prior to entering the Booth at low level. With these control processes, it is possible to achieve between 10-50 µg/m³ OEL when sampling to defined SOP’s.

An example of a layout of a Downflow Booth (DFB) with airlock.

Other News

Antibody Drug Conjugates: The New Wave of Pharmaceuticals

Date: Feb 05, 2018

Blood Cell Labeling 101

Date: Feb 01, 2018

Esco Healthcare Welcomes 2018!

Date: Jan 08, 2018

Isolator-like hot cells are burning this 2018!

Date: Jan 04, 2018

Esco Pharma at the 52nd ASHP Midyear Clinical Meeting and Exhibition 2017

Date: Dec 15, 2017

Bio-decontamination Within
The Efficiency of Esco BioVap™ Inside the Isolators

Date: Nov 28, 2017

Esco Pharma GB exhibited at CPhI and P-Mec in Germany

Date: Nov 08, 2017

Survivor 101: Safe Change Filtration

Date: Nov 07, 2017

The Horror Behind the Gross Art of Sneeze and Cough

Date: Oct 27, 2017

Esco Life Sciences and Healthcare is Strengthening its Core in Biocontainment

Date: Oct 18, 2017

Esco Pharma is at Two Places at Once

Date: Oct 05, 2017

A Perfect Mate

Date: Sep 27, 2017

Nanotechnology: Containment Strategies and Engineering Controls

Date: Sep 26, 2017

It’s more than just being Fragile : How to Handle Potent Formulation?

Date: Sep 25, 2017

Innovative Solutions for the Next Generation: Esco Pharma at ISPE 2017

Date: Aug 30, 2017

How SAFE is your FOOD?

Date: Aug 30, 2017

Nanotechnology in Pharmaceutical R&D: Drug Delivery System

Date: Jul 25, 2017

Inhaled Insulin: Boon or Bane?

Date: Aug 11, 2017

Esco Pharma at High Potent Medicines Conference 2017

Date: Jun 21, 2017

Quality Assurance System

Date: Jun 16, 2017


Date: Jun 16, 2017

Esco Pharma GB is moving!

Date: May 30, 2017

Esco Pharma at INTERPHEX 2017

Date: Apr 04, 2017

Esco Isoclean® Isolators Aid in a Pharmacy Compounding Facility in Singapore

Date: Mar 17, 2017

Esco Pharma Advancing Aseptic Pharmaceutical Processing with SP Scientific PennTech and ESS Technologies

Date: Jan 26, 2017

Esco joins the biggest pharma event in South Asia!

Date: Nov 28, 2016

Feeling Alienated by Safety?

Date: Dec 01, 2016

Blow-Fill-Seal Technology and Isolators

Date: Nov 22, 2016

How Clean is Clean Enough?

Date: Nov 08, 2016

Why isolators are still preferred when handling HPAPIs?

Date: Oct 27, 2016

Be SAFE in Handling High Potency APIs

Date: Oct 26, 2016

Cytotoxic Drugs: Safe Handling in the Workplace!

Date: Oct 17, 2016

Esco isolator finally arrives in the land of the rising sun

Date: Sep 26, 2016

Esco Healthcare exhibits at the 16th ISPE – Singapore Affiliate

Date: Sep 16, 2016

Unidirectional or Turbulent Airflow: Which is best for Sterile Pharmacy Compounding?

Date: Sep 01, 2016

Discover the most diverse compounding pharmacy isolators

Date: Aug 18, 2016

The need for engineering controls in preventing compounding pharmacy mishaps

Date: Jul 19, 2016

Esco at the ASHP in Baltimore!

Date: Jun 23, 2016

Esco at the 2016 PPhA National Convention in Cebu City

Date: Jun 01, 2016

Esco Pharma ships out General Processing Platform Isolator (GPPI) to a client in Canada

Date: Jan 04, 2016

Esco Launches VacciXcell and TapestleRx

Date: Dec 03, 2015

VacciXcell commences the 1st day of exhibition at the Europe Vaccine Congress 2015 in Madrid

Date: Nov 10, 2015

Esco Pharma exhibited concurrently in Pharma Expo Las Vegas and IPEX Packaging Expo in Jakarta

Date: Oct 07, 2015

Esco Pharma partners with UP College of Pharmacy

Date: Jul 09, 2015

Thank you for visiting Esco at ACHEMA 2015!

Date: Jun 26, 2015

Esco at ISPE Exhibition

Date: Jun 09, 2015

Esco Pharma is Proud to Launch its New Range of Containment Isolators

Date: Apr 28, 2015

Esco GB Ltd hosted the 2014 Training at its new premises in Barnsley

Date: Dec 15, 2014

Esco Pharma at ISPE Event in Singapore.

Date: Aug 13, 2014

Esco at INTERPHEX 2014!

Date: Jul 17, 2014