A Perfect Mate

Sep 27, 2017

Trevose, PA – Esco Pharma USA Factory has mated the Esco Weighing and Dispensing Containment Isolator (WDCI) with the Esco Frontier Acela (EFA) Fume Hood. This integrated system simplifies the workflow from weighing and dispensing of potent raw materials, to combining with other materials to make a sample slurry or solution, up to wet chemical analysis. The three-way pass chamber allows a product to be transferred between operations while maintaining maximum personnel protection.

The Esco WDCI is an advanced containment system providing a controlled negative pressure environment to maximize personnel protection during weighing and dispensing of potent products, handling of new chemical entities, and containing of these compounds during sub-division and sampling processes. It is designed for handling potent compounds that fall under Occupational Exposure Band (OEB) Category 5 down to 5 ng/m3 containment protection over an 8-hour TWA.

Esco’s largest range of standard inbuilt configurations allows users to operate for different processes and research and development needs. It is configured with a turbulent airflow with push-push safe change filters allowing maximum containment. Low chamber pressure permits stable and accurate dispensing and weighing of highly potent substances.

Esco WDCI is constructed with fully-welded single piece Outokumpu stainless steel internal chambers with round coved corners. An integrated vacuum oven placed on an elevated surface level inside the isolator provides a fast and economical way of drying sample materials for weighing and dispensing.

 

The isolator is equipped with a nitrogen purge system with oxygen analyzer to maintain an inert environment within the chamber for the processing of potentially explosive dust/gases or hygroscopic products.

A positively pressurized ventilated cabinet underneath the isolator houses the thermostat control module (TCM) which supplies hot or cold process utilities inside the isolator and the fume hood. The inbuilt retort stands in this system allows chemistry process. It also has utility supplies and pass-throughs for process control and measurement devices.

Internal chamber showing integrated oven

The isolator is connected to the fume hood through a pass chamber with interlock mechanism ensuring safety and environment purge sequences between door opening or closures.

The EFA is designed to provide personnel protection against toxic fumes, vapors, and dust. It is also equipped with dual stage Bag-in Bag-out (BIBO) filters, a safe change method for removing contaminated filters. Its secondary function includes protection against chemical spills, runaway reactions, and fires by acting as a physical barrier.

Based on a patented airflow technology, the EFA has unique Hot Zone Baffle design that draws most contaminants back in single pass displacement of the air. With this design, thermal heat relief is quickly achieved. The EFA boasts this exceptional design as it provides a robust stream of bypass air into the hood cavity. The aerodynamic foil entry brings in maximum airflow “sweep” on the critical boundary layer. This helps reduce turbulence and eliminate backflow.

The Sentinel XL facilitates real-time monitoring of the face velocity in EFA. The system generates an alarm once the face velocity is lower or higher than the set points.

Pass chamber connected to fume hood

Esco provides complete integrated containment solutions for every known hazard from chemical processing, potent material handling, aeroallergens, biohazards, and radioactive material manipulation – fume hoods to lead-lined isolators and biosafety cabinets. Utilizing Esco’s own designed and manufactured equipment from its Laboratory and Pharmaceutical Divisions allows single full control over design changes and customization to provide a truly integrated solution to meet the client's needs.

Esco Pharma boasts its strengths on multiple manufacturing sites - Singapore, United Kingdom, and the United States, allowing them to serve customers globally. These three locations utilize the same engineering standards to serve the international market and produce quality equipment with components which are available internationally. Fully certified by ISO 9001, 14001 18001, 13486, Esco is the only company with distributed manufacturing sites but with direct sales and service support from local Esco offices.

 

Contact Esco Pharma to learn more about Esco’s broad range of integrated solutions such as Pharmacon™ Downflow Booths with Flow Hoods and Biological Safety Cabinets.

Esco Technologies Inc – Pharma Division

Eti.pharma@escoglobal.com

215-322-2155

Other News


Raising Your Standards with Esco Downflow Booth
Airflow Containment on Its Best

Date: Nov 29, 2017


Bio-decontamination Within
The Efficiency of Esco BioVap™ Inside the Isolators

Date: Nov 28, 2017


Esco Pharma GB exhibited at CPhI and P-Mec in Germany

Date: Nov 08, 2017


Survivor 101: Safe Change Filtration

Date: Nov 07, 2017


The Horror Behind the Gross Art of Sneeze and Cough

Date: Oct 27, 2017


Esco Life Sciences and Healthcare is Strengthening its Core in Biocontainment

Date: Oct 18, 2017


Esco Pharma is at Two Places at Once

Date: Oct 05, 2017


Nanotechnology: Containment Strategies and Engineering Controls

Date: Sep 26, 2017


It’s more than just being Fragile : How to Handle Potent Formulation?

Date: Sep 25, 2017


Innovative Solutions for the Next Generation: Esco Pharma at ISPE 2017

Date: Aug 30, 2017


How SAFE is your FOOD?

Date: Aug 30, 2017


Nanotechnology in Pharmaceutical R&D: Drug Delivery System

Date: Jul 25, 2017


Inhaled Insulin: Boon or Bane?

Date: Aug 11, 2017


Esco Pharma at High Potent Medicines Conference 2017

Date: Jun 21, 2017


Quality Assurance System

Date: Jun 16, 2017


Defects

Date: Jun 16, 2017


Esco Pharma GB is moving!

Date: May 30, 2017


Esco Pharma at INTERPHEX 2017

Date: Apr 04, 2017


Esco Isoclean® Isolators Aid in a Pharmacy Compounding Facility in Singapore

Date: Mar 17, 2017


Esco Pharma Advancing Aseptic Pharmaceutical Processing with SP Scientific PennTech and ESS Technologies

Date: Jan 26, 2017


Esco joins the biggest pharma event in South Asia!

Date: Nov 28, 2016


Feeling Alienated by Safety?

Date: Dec 01, 2016


Blow-Fill-Seal Technology and Isolators

Date: Nov 22, 2016


How Clean is Clean Enough?

Date: Nov 08, 2016


Why isolators are still preferred when handling HPAPIs?

Date: Oct 27, 2016


Be SAFE in Handling High Potency APIs

Date: Oct 26, 2016


Cytotoxic Drugs: Safe Handling in the Workplace!

Date: Oct 17, 2016


Esco isolator finally arrives in the land of the rising sun

Date: Sep 26, 2016


Esco Healthcare exhibits at the 16th ISPE – Singapore Affiliate

Date: Sep 16, 2016


Unidirectional or Turbulent Airflow: Which is best for Sterile Pharmacy Compounding?

Date: Sep 01, 2016


Discover the most diverse compounding pharmacy isolators

Date: Aug 18, 2016


The need for engineering controls in preventing compounding pharmacy mishaps

Date: Jul 19, 2016


Esco at the ASHP in Baltimore!

Date: Jun 23, 2016


Esco at the 2016 PPhA National Convention in Cebu City

Date: Jun 01, 2016


Esco Pharma ships out General Processing Platform Isolator (GPPI) to a client in Canada

Date: Jan 04, 2016


Esco Launches VacciXcell and TapestleRx

Date: Dec 03, 2015


VacciXcell commences the 1st day of exhibition at the Europe Vaccine Congress 2015 in Madrid

Date: Nov 10, 2015


Esco Pharma exhibited concurrently in Pharma Expo Las Vegas and IPEX Packaging Expo in Jakarta

Date: Oct 07, 2015


Esco Pharma partners with UP College of Pharmacy

Date: Jul 09, 2015


Thank you for visiting Esco at ACHEMA 2015!

Date: Jun 26, 2015


Esco at ISPE Exhibition

Date: Jun 09, 2015


Esco Pharma is Proud to Launch its New Range of Containment Isolators

Date: Apr 28, 2015


Esco GB Ltd hosted the 2014 Training at its new premises in Barnsley

Date: Dec 15, 2014


Esco Pharma at ISPE Event in Singapore.

Date: Aug 13, 2014


Esco at INTERPHEX 2014!

Date: Jul 17, 2014