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Cartridge

Cartridge – usually cylindrical, suitable for liquid or solid pharmaceutical dosage forms; generally for use in a specifically designed apparatus. (e.g. prefilled syringes).

Cartridge Cleaning

    1. Cleaning via ultrasonic washing machine – this machine is mainly used in the pharmaceutical industry for small volume ampoule cleaning.
    2. Cleaning via  sterilization dryer – mainly used on the injection linked production line of pharmaceutical factories. It can continuously dry, sterilize and remove pyrogen of the washed ampoule.

Cartridge Depyrogenation

Involves the sterilization of the cartridge with hot air and constantly recirculated. The cartridge are then cooled gently before they are automatically transferred into the next production process.

Cartridge Dosing

  • Peristaltic Pump Filling

    The peristaltic pump uses a rotor in which multiple rollers are mounted. Partially surrounding the rotor is a stationary, curved shoe or “anvil”. A flexible, hollow tube (usually silicone rubber) is pinched between each roller and the shoe. As the rotor rotates, fluid inside the tube is driven forward as the pinched portion of the tubing advances.

  • Piston Pumps

    The piston pump, along with the rolling diaphragm pump, may be compared to a syringe in that they both employ a moving piston inside a stationary cylinder to displace a precise amount of liquid. As the piston moves upward, liquid is forced out of the pump and when it moves downward, liquid is drawn into the pump.

  • Rolling Diaphragm Pump

    The rolling diaphragm pump uses a flexible membrane (diaphragm) attached to the pump body at its outside diameter and to the piston at its inside diameter. A space between the piston and the body internal body cylinder allows the diaphragm to be “doubled” and to “roll” as the piston moves up and down. Vacuum is applied to a port in the lower portion of the pump body to maintain the shape of the diaphragm and to pull the piston downward on the refill portion of the filling cycle. Typically, the product supply has a slight overpressure.

Cartridge Filling

  • Time Pressure Filling

    A time pressure filling system in its simplest form, includes a product supply vessel under controlled pressure, a valve to open and close the product flow from the tank to the filling needle, and a clock or timing device to repeatedly control the amount of time that the valve is open.

  • Fill by weight

    The product supply tank may or may not be pressurized, and a flow orifice may be used to improve repeatability.

  • Mass Flow Filling

    The product supply tank may be pressurized at a control pressure, or may use a precisely controlled liquid level (gravity feed). For small fills, common in pharmaceutical filling, a pressurized system provides more precise fill volume control and acceptable cycle rates.

  • Gravimetric Filling

    A gravimetric filling system is simply a system that uses gravity, or a controlled liquid height, to provide a consistent pressure at the metering device near the filling needle. A simple time pressure filling system or a fill by weight system may be gravimetric. These system use a “clock” and a valve (time pressure) and a scale and a valve (fill by weight) for metering doses.

Cartridge Labelling

Containers are fed from an upstream machine then gently transferred to the labeling station and applied to the containers by smoothing belts and rollers.

Cartridge Tray Loading

Products are collated onto tray banks, hence product stabilization is established and controlled throughout the process.