Blister – a multi-dose container consisting of two layers, of which one is shaped to contain the individual doses. Strips are excluded.

Uses of Blister Packaging in Pharmaceutical Industry

  1. They provide barrier protection for shelf life requirements.
  2. They also provide a degree of tamper resistance.
  3. It can offer patients a clearly marked individual dose, enabling them to check whether they had taken the prescribed drugs on a given day.
  4. When the drugs that were not taken remained in the original package and were fully protected against adverse external conditions.
  5. The patient could handle the blister package more easily and could store it more conveniently than conventional packages.
  6. Protection from moisture, gas, light and temperature.

Advantages of Blister Type Packaging

  1. Prevention of broken glass bottles.
  2. Reduced costs and higher packaging speeds relative to other packaging materials.
  3. Blister packaging helps retain product integrity since drugs that are prepackaged in blisters are shielded from adverse conditions.
  4. Opportunities for product contamination are minimal.
  5. Each dose is identified by product name, lot number and expiration date.
  6. Individually sealed in constructions of plastic, foil and/or paper. Tamper evidence is another strength of blister packaging. Each tablet or capsule is individually protected from tampering until use.

Blister Packaging Machinery

Modern thermoform-fill-seal machined can operate at speeds ≤ 800 packages/min. Emphasis in improving production is placed on applying microprocessor controls that electronically connect the filling and forming equipment with other downstream machinery for cartoning and wrapping. These controls also feed tablets or liquids into the unit-dose blisters, ensuring that an exact volume is put into each. Modern machinery also uses integrated vision systems to help ensure the accuracy of the fill and the integrity of the product in the blister. These machines have become quite versatile and can readily accommodate several lidstocks and basestock, allowing the manufacturer to obtain better compatibility between the medicine and its packaging material as well as better patient compliance.