DRUG DOSAGE FORMS & DELIVERY SYSTEMS


Topical Solutions

Overview

Generally, the topical solutions employ an aqueous vehicle, whereas the topical tinctures characteristically employ an alcoholic vehicle. As required, co solvents or adjuncts to enhance stability or the solubility of the solute are employed.

Most topical solutions and tinctures are prepared by simple dissolving. However, certain solutions are prepared by chemical reaction; these, in particular, are discussed later in this section. Of the tinctures for topical use, one, compound benzoin tincture, is prepared by maceration of the natural components in the solvent; the others are prepared by simple solution.

Because of the nature of the active constituents or the solvents, many topical solutions and tinctures are self-preserved. Those that are not may contain suitable preservatives. Topical solutions and tinctures should be packaged in containers that make them convenient to use. Those that are used in small volume, such as the anti-infective, are usually packaged in glass or plastic bottles with an applicator tip as a part of the cap assembly or in plastic squeeze bottles that deliver the medication in drops. Many of the anti-infective solutions and tinctures contain a dye to delineate the area of application to the skin. In contrast to aqueous solutions, when the alcoholic tinctures are applied to abraded or broken skin, they sting.