DRUG DOSAGE FORMS & DELIVERY SYSTEMS


Douches

Solutions may be prepared from powders as indicated earlier or from liquid solutions or liquid concentrates. In using liquid concentrates, the patient is instructed to add the prescribed amount of concentrate (usually a teaspoonful or capful) to a certain amount of warm water (frequently a quart). The resultant solution contains the appropriate amount of chemical agents in proper strength. The agents are similar to the ones described for douche powders.

Powders are used to prepare solutions for vaginal douche, i.e., for irrigation cleansing of the vagina. The powders themselves may be prepared and packaged in bulk or as unit packages. A unit package is designed to contain the appropriate amount of powder to prepare the specifi ed volume of douche solution. The bulk powders are used by the teaspoonful or tablespoonful in preparation of the desired solution. The user simply adds the prescribed amount of powder to the appropriate volume of warm water and stirs until dissolved.

Among the components of douche powders are the following:

  1. Boric acid or sodium borate
  2. Astringents, for example, potassium, alum, ammonium alum, zinc sulfate
  3. Antimicrobials, for example, oxyquinoline sulfate, povidone iodine
  4. Quaternary ammonium compounds, for example, benzethonium chloride
  5. Detergents, for example, sodium lauryl sulfate
  6. Oxidizing agents, for example, sodium perborate
  7. Salts, for example, sodium citrate, sodium chloride
  8. Aromatics, for example, menthol, thymol, eucalyptol, methyl salicylate, phenol

Douche powders are used for their hygienic effects. A few douche powders containing specific therapeutic anti-infective agents such as those mentioned in the discussion of vaginal suppositories are used against monilial and trichomonal infections.